4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 35973-18-3
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.19
• Hs Code.: 2933499090
• Mol file: 35973-18-3.mol

Synonyms:4-Hydroxy-6-methylquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 1,4-dihydro-6-methyl-4-oxo-;3-Quinolinecarboxylic acid, 4-hydroxy-6-methyl-;

Chemical Property of 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.65E-06mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 381.7 °C at 760 mmHg
• Flash Point: 184.7 °C
• PSA: 70.42000
• Density: 1.367 g/cm³
• LogP: 1.94700
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-6-methylquinoline-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-6-methylquinoline-3-carboxylic acid

Technology Process of 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID

There total 5 articles about 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-hydroxy-6-methylquinoline-3-carboxylate (85418-82-2) → 4-hydroxy-6-methyl-quinoline-3-carboxylic acid (35973-18-3)

Guidance literature:

With sodium hydroxide;

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 4-hydroxy-6-methyl-quinoline-3-carboxylic acid (35973-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 1 h / Heating

1.2: 45 percent / diphenyl ether / 1 h / Heating

2.1: aq. sodium hydroxide / 1 h / Heating

With sodium hydroxide; In toluene;

DOI:10.1248/cpb.55.821

Reference yield:

diethyl 2-[(p-tolylamino)methylidene]malonate (19056-84-9) → 4-hydroxy-6-methyl-quinoline-3-carboxylic acid (35973-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: paraffin oil / 290 °C

2: aqueous NaOH

With sodium hydroxide; paraffin oil;

upstream raw materials:

ethyl 4-hydroxy-6-methylquinoline-3-carboxylate

diethyl malonate

N,N'-di-p-tolylformamidine

p-toluidine

Downstream raw materials:

4-hydroxy-6-methylquinoline