3-(Benzyloxy)-5-broMo-2-chloropyridine

Base Information

• Chemical Name: 3-(Benzyloxy)-5-broMo-2-chloropyridine
• CAS No.: 891785-18-5
• Molecular Formula: C12H9BrClNO
• Molecular Weight: 298.567
• Hs Code.: 2933399090
• Mol file: 891785-18-5.mol

Synonyms:3-(Benzyloxy)-5-broMo-2-chloropyridine

Chemical Property of 3-(Benzyloxy)-5-broMo-2-chloropyridine

Chemical Property:

• PSA: 22.12000
• LogP: 4.07650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(Benzyloxy)-5-bromo-2-chloropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Benzyloxy)-5-broMo-2-chloropyridine

There total 9 articles about 3-(Benzyloxy)-5-broMo-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-chloro-3-hydroxypyridine (286946-77-8) + benzyl bromide (100-39-0) → 3-(benzyloxy)-5-bromo-2-chloropyridine (891785-18-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 95.0%

5-bromo-3-(benzyloxy)pyridine N-oxide (552330-34-4) → 3-(benzyloxy)-5-bromo-2-chloropyridine (891785-18-5)

Guidance literature:

With trichlorophosphate; In dichloromethane; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.035

Reference yield:

3-(benzyloxy)-5-bromopyridine-2-amine (754230-78-9) → 3-(benzyloxy)-5-bromo-2-chloropyridine (891785-18-5) + 3-(benzyloxy)-5-bromo-2-iodopyridine (1342906-74-4)

Guidance literature:

With copper(l) iodide; iodine; 1,2-dichloro-ethane; isopentyl nitrite; at 85 ℃; for 0.166667h;

DOI:10.1016/j.tet.2011.09.024

upstream raw materials:

5-bromo-3-(benzyloxy)pyridine N-oxide

3,5-dibromopyridine

3-(benzyloxy)-5-bromopyridine

benzyl alcohol

Downstream raw materials:

ethyl 3-amino-6-(3-{[(3-chlorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate

ethyl 3-amino-6-(3-{[(3-fluorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate

ethyl 3-amino-6-(3-{[(3-biphenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate

ethyl 3-amino-6-(3-{[(4-chlorophenyl)amino]carbonyl}phenyl)furo[3,2-b]pyridine-2-carboxylate

Refernces

• 1、 Bretéché, Anne,Marchand, Pascal,Nourrisson, Marie-Renée,Hautefaye, Patrick,De Nanteuil, Guillaume,Duflos, Muriel. "A convenient route to functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2- carboxamides". . p. 4767 - 4773. Retrieved 2011/07/31.
• 2、 -. "INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS". Page/Page column 37. . Retrieved 2011/10/03.