2-(Boc-aMinoMethyl)pyriMidine

Base Information

• Chemical Name: 2-(Boc-aMinoMethyl)pyriMidine
• CAS No.: 1260843-26-2
• Molecular Formula: C10H15N3O2
• Molecular Weight: 209.248
• Mol file: 1260843-26-2.mol

Synonyms:2-(Boc-aMinoMethyl)pyriMidine;2-(Boc-aMinoMethyl)pyriMi...;tert-butyl N-(pyrimidin-2-ylmethyl)carbamate

Chemical Property of 2-(Boc-aMinoMethyl)pyriMidine

Chemical Property:

• PSA: 67.60000
• LogP: 1.70570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(Boc-aminomethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Boc-aMinoMethyl)pyriMidine

There total 3 articles about 2-(Boc-aMinoMethyl)pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-aminomethylpyrimidine (75985-45-4) → tert-butyl (pyrimidin-2-ylmethyl)carbamate (1260843-26-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

Reference yield:

2-cyanopyrimidine (14080-23-0) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (pyrimidin-2-ylmethyl)carbamate (1260843-26-2)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydroxide; In water; ethyl acetate; at 20 - 25 ℃; for 16h; under 1520.1 Torr; Reagent/catalyst; Concentration; Temperature; Pressure; Sealed tube; Inert atmosphere;

Reference yield:

2-cyanopyrimidine (14080-23-0) → tert-butyl (pyrimidin-2-ylmethyl)carbamate (1260843-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 760.05 Torr / Inert atmosphere

2: triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol;

upstream raw materials:

2-cyanopyrimidine

di-tert-butyl dicarbonate

2-aminomethylpyrimidine

Downstream raw materials:

1-(pyrimidin-2-yl)methanamine hydrochloride

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