2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE
• CAS No.: 372118-67-7
• Molecular Formula: C5H7N3^.HCl
• Molecular Weight: 145.592
• Hs Code.: 2933599090
• Mol file: 372118-67-7.mol

Synonyms:2-Pyrimidinemethanamine,monohydrochloride (9CI);

Chemical Property of 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.102mmHg at 25°C
• Boiling Point: 218.7 °C at 760 mmHg
• Flash Point: 86.1 °C
• PSA: 51.80000
• LogP: 1.43760
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

2-PyrimidinemethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
• Uses: 2-Pyrimidinemethanamine Hydrochloride is a reagent and an intermediate that is used for pharmaceutical synthesis such as spirocyclic acylguanidines as beta-secretase inhibitors for treatment of neurodegenerative disorders.

Technology Process of 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE

There total 4 articles about 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-aminomethylpyrimidine methanesulfonate → 1-(pyrimidin-2-yl)methanamine hydrochloride (372118-67-7)

Guidance literature:

2-aminomethylpyrimidine methanesulfonate; With sodium methylate; at -10 ℃; for 1h;

With hydrogenchloride; at -10 ℃; for 2h; Temperature;

Reference yield: 44.0%

2-cyanopyrimidine (14080-23-0) → 1-(pyrimidin-2-yl)methanamine hydrochloride (372118-67-7)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 3h;

Reference yield:

tert-butyl (pyrimidin-2-ylmethyl)carbamate (1260843-26-2) → 1-(pyrimidin-2-yl)methanamine hydrochloride (372118-67-7)

Guidance literature:

With hydrogenchloride; In water;

upstream raw materials:

2-cyanopyrimidine

tert-butyl (pyrimidin-2-ylmethyl)carbamate

Downstream raw materials:

N-pyrimidin-2-ylmethyl-4-trifluoromethyl-nicotinamide

Refernces

• 1、 -. "Preparation method of 2-amido methylpyrimidine hydrochloride". Paragraph 0013; 0014; 0015; 0016; 0017; 0018; 0019; 0020. . Retrieved 2017/06/02.
• 2、 -. "SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF". Paragraph 0139. . Retrieved 2014/08/19.