5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE
• CAS No.: 916326-37-9
• Molecular Formula: C₇H₄BrN₃O
• Molecular Weight: 226.032
• Mol file: 916326-37-9.mol

Synonyms:5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE;5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxaldehyde

Chemical Property of 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 5.87E-07mmHg at 25°C
• Boiling Point: 410.8°C at 760 mmHg
• PKA: 6.70±0.40(Predicted)
• Flash Point: 202.2°C
• PSA: 58.64000
• Density: 1.945g/cm³
• LogP: 1.53290
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

5-Bromo-1H-pyrazolo[3,4-B]pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE is a useful research chemical.

Technology Process of 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE

There total 4 articles about 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-7-azaindazole (875781-17-2,916257-29-9) + hexamethylenetetramine (100-97-0) → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde (916326-37-9)

Guidance literature:

With acetic acid; In water; for 12h; Reflux;

DOI:10.1007/s00044-016-1671-2

Reference yield: 69.0%

C9H10BrN3O2 → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde (916326-37-9)

Guidance literature:

C₉H₁₀BrN₃O₂; With pyrographite; In ethyl acetate; at 20 - 25 ℃;

With hydrogenchloride; In 2-methyltetrahydrofuran; water; at 5 - 40 ℃;

Reference yield:

5-bromo-2-fluoropyridine (766-11-0) → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde (916326-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene; tetrahydrofuran / 20 - 25 °C / Inert atmosphere

1.2: 20 - 25 °C / Inert atmosphere

1.3: 20 - 25 °C / Inert atmosphere

2.1: hydrazine hydrate / toluene; 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 20 - 100 °C / Inert atmosphere

3.1: pyrographite / ethyl acetate / 20 - 25 °C

3.2: 5 - 40 °C

With pyrographite; hydrazine hydrate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl acetate; toluene;

upstream raw materials:

5-bromo-7-azaindazole

hexamethylenetetramine

5-bromo-2-fluoropyridine

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