2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 957061-13-1
• Molecular Formula: C15H22BBrO3
• Molecular Weight: 341.053
• Hs Code.: 2934999090
• Mol file: 957061-13-1.mol

Synonyms:4-(3-Bromopropoxy)phenylboronic acid, pinacol ester;4-(3-Bromopropoxy)benzeneboronicacid,pinacolester98%

Chemical Property of 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 413.3±30.0 °C(Predicted)
• PSA: 27.69000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 3.14960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-(3-Bromopropoxy)phenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 1 articles about 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,3-dibromo-propane (109-64-8) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → 2-[4-(3-bromopropoxy)phenyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane (957061-13-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃; for 7h;

Reference yield: 84.0%

2-[4-(3-bromopropoxy)phenyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane (957061-13-1) + (R)-2-methylpyrrolidine hydrochloride (41720-98-3,54677-53-1,135324-85-5,174500-74-4) → (R)-2-methyl-1-{3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxyl]propyl}pyrrolidine (1005403-35-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 78 ℃; for 36h;

Reference yield: 73.0%

tert-butyl 3-methoxy-4-(4-methylpiperidin-4-ylcarbamoyl)phenylcarbamate (1186220-73-4) + 2-[4-(3-bromopropoxy)phenyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane (957061-13-1) → tert-butyl (3-methoxy-4-((4-methyl-1-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)piperidin-4-yl)carbamoyl)phenyl)carbamate

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/acsmedchemlett.0c00658

upstream raw materials:

1,3-dibromo-propane

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Downstream raw materials:

(R)-2-methyl-1-{3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxyl]propyl}pyrrolidine

N-ethyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propan-1-amine

1-(methylsulfonyl)-4-{3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl}-piperazine

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