3-(2-Phenyl-thiazol-4-yl)-phenylamine

Base Information

• Chemical Name: 3-(2-Phenyl-thiazol-4-yl)-phenylamine
• CAS No.: 134812-32-1
• Molecular Formula: C15H12N2S
• Molecular Weight: 252.33
• Hs Code.: 2934100090
• European Community (EC) Number: 673-331-7
• DSSTox Substance ID: DTXSID50353295
• Wikidata: Q72498937
• Mol file: 134812-32-1.mol

Synonyms:134812-32-1;3-(2-Phenyl-thiazol-4-yl)-phenylamine;3-(2-phenyl-1,3-thiazol-4-yl)aniline;3-(2-phenylthiazol-4-yl)aniline;3-(2-phenylthiazol-4-yl)-aniline;3-(2-phenylthiazol-4-yl)phenylamine;Oprea1_019940;Oprea1_608322;F1912-0012;DTXSID50353295;STL195410;AKOS009038587;CCG-310355;FS-6373;EN300-236199;SR-01000449572;SR-01000449572-1;F0804-1566

Chemical Property of 3-(2-Phenyl-thiazol-4-yl)-phenylamine

Chemical Property:

• PSA: 67.15000
• LogP: 4.64050
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 252.07211956
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Phenyl-thiazol-4-yl)-phenylamine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CS2)C3=CC(=CC=C3)N
• Uses: 3-(2-Phenyl-thiazol-4-yl)-phenylamine is used in the preparation of Quinolone antibacterials

Technology Process of 3-(2-Phenyl-thiazol-4-yl)-phenylamine

There total 4 articles about 3-(2-Phenyl-thiazol-4-yl)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3'-amino-2-bromoacetophenone hydrobromide (15473-81-1) + benzenecarbothioamide (2227-79-4) → 3-(2-Phenyl-thiazol-4-yl)-phenylamine (134812-32-1)

Guidance literature:

In ethanol; at 50 ℃; for 2h;

DOI:10.1002/jhet.5570280323

Reference yield:

1-(3-aminophenyl)ethanone (99-03-6) → 3-(2-Phenyl-thiazol-4-yl)-phenylamine (134812-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Ac₂O / 48 h / Ambient temperature

2: 80 percent / Br₂ / CHCl₃ / 0.5 h / Heating

3: 89 percent / ethanol / 2 h / 50 °C

With bromine; acetic anhydride; In ethanol; chloroform;

DOI:10.1002/jhet.5570280323

Reference yield:

1-(3-formylaminophenyl)ethanone (72801-78-6) → 3-(2-Phenyl-thiazol-4-yl)-phenylamine (134812-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Br₂ / CHCl₃ / 0.5 h / Heating

2: 89 percent / ethanol / 2 h / 50 °C

With bromine; In ethanol; chloroform;

DOI:10.1002/jhet.5570280323

upstream raw materials:

3'-amino-2-bromoacetophenone hydrobromide

benzenecarbothioamide

1-(3-aminophenyl)ethanone

1-(3-formylaminophenyl)ethanone

Downstream raw materials:

C₁₆H₁₃N₃S₂

1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid