Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate

Base Information

• Chemical Name: Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate
• CAS No.: 6046-71-5
• Molecular Formula: C₁₅H₁₇NO₆
• Molecular Weight: 307.303
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70572749
• Nikkaji Number: J28.308H
• Wikidata: Q82461226
• Mol file: 6046-71-5.mol

Synonyms:6046-71-5;Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate;4-hydroxy-5,6,8-trimethoxyquinoline-2-Carboxylic ethylate;ethyl 5,6,8-trimethoxy-4-oxo-1H-quinoline-2-carboxylate;DTXSID70572749;AKOS015897058;SB72709;Ethyl4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate;Ethyl 5,6,8-trimethoxy-4-oxo-1,4-dihydroquinoline-2-carboxylate

Chemical Property of Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate

Chemical Property:

• PSA: 87.11000
• LogP: 2.14290
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 307.10558726
• Heavy Atom Count: 22
• Complexity: 463

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC(=O)C2=C(N1)C(=CC(=C2OC)OC)OC

Technology Process of Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate

There total 1 articles about Ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,5-trimethoxyaniline (26510-91-8) + diethyl oxaloacetate (108-56-5) → 4-hydroxy-5,6,8-trimethoxy-quinoline-2-carboxylic acid ethyl ester (6046-71-5)

Guidance literature:

Erhitzen des Reaktionsprodukts in Paraffinoel auf 240grad;

Reference yield:

4-hydroxy-5,6,8-trimethoxy-quinoline-2-carboxylic acid ethyl ester (6046-71-5) → xanthommatin (521-58-4,22694-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HBr / Behandeln des Reaktionsprodukts mit K₃ und NaHCO₃ in H₂O

2: aqueous acetic acid

With hydrogen bromide; acetic acid;

Reference yield:

4-hydroxy-5,6,8-trimethoxy-quinoline-2-carboxylic acid ethyl ester (6046-71-5) → 4,6-dihydroxy-5,8-dioxo-5,8-dihydro-quinoline-2-carboxylic acid (98948-82-4)

Guidance literature:

With hydrogen bromide; Behandeln des Reaktionsprodukts mit K3 und NaHCO3 in H2O;

upstream raw materials:

2,4,5-trimethoxyaniline

diethyl oxaloacetate

Downstream raw materials:

4,6-dihydroxy-5,8-dioxo-5,8-dihydro-quinoline-2-carboxylic acid

xanthommatin

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