2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester
• CAS No.: 742067-22-7
• Molecular Formula: C₁₄H₂₆N₂O₄S
• Molecular Weight: 318.437
• Mol file: 742067-22-7.mol

Synonyms:2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Chemical Property of 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Chemical Property:

• Vapor Pressure: 8.45E-08mmHg at 25°C
• Boiling Point: 435.9°C at 760 mmHg
• Flash Point: 217.4°C
• PSA: 75.30000
• Density: 1.23g/cm³
• LogP: 3.01570

Purity/Quality:

98% ^*data from raw suppliers

8-(METHYLSULFONYL)-2,8-DIAZASPIRO[4.5]DECANE-2-CARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

There total 1 articles about 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (336191-17-4) → 8-methane sulfonyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (742067-22-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 8-methane sulfonyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (742067-22-7) → 8-methanesulfonyl-2,8-diaza-spiro[4.5]decane hydrochloride (742067-21-6)

Guidance literature:

In ethyl acetate; at 20 ℃; for 2h;

upstream raw materials:

methanesulfonyl chloride

tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

Downstream raw materials:

8-methanesulfonyl-2,8-diaza-spiro[4.5]decane hydrochloride