Flupirtine DiMer

Base Information

• Chemical Name: Flupirtine DiMer
• CAS No.: 1417916-52-9
• Molecular Formula: C30H32F2N8O4
• Molecular Weight: 606.6230864
• Mol file: 1417916-52-9.mol

Synonyms:Flupirtine DiMer;Flupirtine Maleate impurity D14461

Chemical Property of Flupirtine DiMer

Chemical Property:

• PSA: 178.54000
• LogP: 7.40160

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Flupirtine DiMer

There total 6 articles about Flupirtine DiMer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate (1422275-80-6) → diethyl {6,6'-diamino-2,2'-bis[(4-fluorobenzyl)amino]-3,3'-bipyridine-5,5'-diyl}biscarbamate (1417916-52-9)

Guidance literature:

With triethylamine; triphenylphosphine; nickel dichloride; zinc; In tetrahydrofuran; at 60 ℃; for 48h; Inert atmosphere;

DOI:10.5560/ZNB.2012-0258

Reference yield:

C12H12BrFN4 (1422275-79-3) → diethyl {6,6'-diamino-2,2'-bis[(4-fluorobenzyl)amino]-3,3'-bipyridine-5,5'-diyl}biscarbamate (1417916-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 2 h / 0 °C

2: nickel dichloride; triphenylphosphine; triethylamine; zinc / tetrahydrofuran / 48 h / 60 °C / Inert atmosphere

With triethylamine; triphenylphosphine; nickel dichloride; zinc; In tetrahydrofuran;

DOI:10.5560/ZNB.2012-0258

Reference yield:

2-amino-6-chloro-3-nitropyridine (27048-04-0) → diethyl {6,6'-diamino-2,2'-bis[(4-fluorobenzyl)amino]-3,3'-bipyridine-5,5'-diyl}biscarbamate (1417916-52-9)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / isopropyl alcohol / 10 h / Reflux

2: N-Bromosuccinimide; ammonium acetate / tetrahydrofuran; acetonitrile / 3 h / 0 °C

3: ammonium acetate; zinc / ethyl acetate; water / 1 h / 35 °C

4: triethylamine / 2 h / 0 °C

5: nickel dichloride; triphenylphosphine; triethylamine; zinc / tetrahydrofuran / 48 h / 60 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium acetate; triethylamine; triphenylphosphine; nickel dichloride; zinc; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol; acetonitrile;

DOI:10.5560/ZNB.2012-0258

upstream raw materials:

ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

C₁₂H₁₂BrFN₄

2-amino-6-chloro-3-nitropyridine

para-fluorobenzylamine