ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

Base Information

Chemical Name:ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate
CAS No.:1422275-80-6
Molecular Formula:C₁₅H₁₆BrFN₄O₂
Molecular Weight:383.22
Hs Code.:

Synonyms:ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

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Chemical Property of ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

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Technology Process of ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

There total 4 articles about ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

: 1422275-79-3
C₁₂H₁₂BrFN₄

: 541-41-3
chloroformic acid ethyl ester

: 1422275-80-6
ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

: 1422275-81-7
diethyl 6-bromo-5-[(4-fluorobenzyl)amino]-2-oxo-1H-imidazo[4,5-b]pyridine-1,3(2H)-dicarboxylate

Guidance literature:: With triethylamine; at 0 ℃; for 2h;
DOI:10.5560/ZNB.2012-0258

Reference yield:

: 140-75-0
para-fluorobenzylamine

: 1422275-80-6
ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

: 1422275-81-7
diethyl 6-bromo-5-[(4-fluorobenzyl)amino]-2-oxo-1H-imidazo[4,5-b]pyridine-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 10 h / Reflux

2: N-Bromosuccinimide; ammonium acetate / tetrahydrofuran; acetonitrile / 3 h / 0 °C

3: ammonium acetate; zinc / ethyl acetate; water / 1 h / 35 °C

4: triethylamine / 2 h / 0 °C

With N-Bromosuccinimide; ammonium acetate; triethylamine; zinc; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.5560/ZNB.2012-0258

Reference yield:

: 33400-49-6
2-amino-3-nitro-6-(p-fluoro-benzylamino)-pyridine

: 1422275-80-6
ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate

: 1422275-81-7
diethyl 6-bromo-5-[(4-fluorobenzyl)amino]-2-oxo-1H-imidazo[4,5-b]pyridine-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; ammonium acetate / tetrahydrofuran; acetonitrile / 3 h / 0 °C

2: ammonium acetate; zinc / ethyl acetate; water / 1 h / 35 °C

3: triethylamine / 2 h / 0 °C

With N-Bromosuccinimide; ammonium acetate; triethylamine; zinc; In tetrahydrofuran; water; ethyl acetate; acetonitrile;
DOI:10.5560/ZNB.2012-0258