LCZ Impurity

Base Information Edit

Chemical Name:LCZ Impurity
CAS No.:753421-85-1
Molecular Formula:C₂₀H₂₅NO₂
Molecular Weight:311.424
Hs Code.:
Mol file:753421-85-1.mol

Synonyms:LCZ Impurity;Sacubitril Impurity 11;Sacubitril Impurity 12;Sacubitril Impurity 13;Sacubitril Impurity 14;Sacubitril Impurity 15;Sacubitril Impurity 16;Sacubitril Impurity 17

Suppliers and Price of LCZ Impurity

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of LCZ Impurity Edit

Chemical Property:

Boiling Point:459.1±45.0 °C(Predicted)
PKA:9.58±0.42(Predicted)
PSA：35.25000
Density:1.057±0.06 g/cm3(Predicted)
LogP:5.50010

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of LCZ Impurity

There total 53 articles about LCZ Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 64-17-5
ethanol

: 1039307-95-3
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid

: 752174-62-2,753421-85-1
(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

Guidance literature:: With thionyl chloride; at 40 - 70 ℃;

Reference yield: 90.1%

: (R)-5-([1,1`-biphenyl]-4-yl)-2-methyl-4-pentanone ethyl ester

: 752174-62-2,753421-85-1
(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

Guidance literature:: With hydrogenchloride; tris(hydroxymethyl)aminomethyl-hydrochloric acid; pyridoxal 5'-phosphate; isopropylamine; In water; dimethyl sulfoxide; at 35 - 40 ℃; for 24h; pH=7.5 - 8.0;