1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one

Base Information

• Chemical Name: 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one
• CAS No.: 1210828-42-4
• Molecular Formula: C₂₆H₂₁FN₂O₆
• Molecular Weight: 476.461

Synonyms:1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one

Chemical Property of 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one

There total 2 articles about 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one (649736-31-2) + 7-(benzyloxy)-4-chloro-6-methoxyquinoline (286371-49-1) → 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one (1210828-42-4)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In 1-methyl-pyrrolidin-2-one; at 100 ℃;

Reference yield:

7-(benzyloxy)-4-(3-(2,2-dimethoxypropyl)-2-fluoro-4-nitrophenoxy)-6-methoxyquinoline (1210828-41-3) → 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one (1210828-42-4)

Guidance literature:

With hydrogenchloride; In water; acetone; for 6h; Reflux;

Reference yield: 75.0%

1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one (1210828-42-4) → 4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxy-7-hydroxyquinoline (1210828-44-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 50 - 55 ℃; under 1125.11 - 1500.15 Torr;

upstream raw materials:

7-(benzyloxy)-4-(3-(2,2-dimethoxypropyl)-2-fluoro-4-nitrophenoxy)-6-methoxyquinoline

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Downstream raw materials:

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-benzyloxyquinoline

4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxy-7-hydroxyquinoline

1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine dihydrochloride

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