7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid

Base Information

• Chemical Name: 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid
• CAS No.: 441353-52-2
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.287
• Hs Code.: 2933990090
• Mol file: 441353-52-2.mol

Synonyms:7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid;7-Azabicyclo[2.2.1]heptane-1,7-dicarboxylic acid, 7-(1,1-diMethylethyl) ester

Chemical Property of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid

Chemical Property:

• Boiling Point: 363.3±25.0 °C(Predicted)
• PKA: 4.21±0.20(Predicted)
• PSA: 66.84000
• Density: 1.266±0.06 g/cm3(Predicted)
• LogP: 1.94100

Purity/Quality:

97% ^*data from raw suppliers

7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid

There total 5 articles about 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester (182137-51-5) → Boc-Ach-OH (441353-52-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jo016406r

Reference yield: 53.0%

carbon dioxide (124-38-9,18923-20-1) + 7-tert-butoxycarbonyl-7-azabicyclo<2.2.1>heptane (188624-94-4) → Boc-Ach-OH (441353-52-2)

Guidance literature:

7-tert-butoxycarbonyl-7-azabicyclo<2.2.1>heptane; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at 0 ℃;

carbon dioxide; In diethyl ether; cyclohexane;

DOI:10.1016/j.tetlet.2010.10.079

Reference yield:

1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester (182137-57-1) → Boc-Ach-OH (441353-52-2)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 4h;

DOI:10.1016/S0040-4020(02)00388-5

upstream raw materials:

1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

methyl N-benzoyl-7-azabicyclo[2.2.1]heptane-1-carboxylate

7-benzyl-1-hydroxymethyl-7-azabicyclo[2.2.1]heptane

Downstream raw materials:

7-azabicyclo[2.2.1]heptane-1-carboxylic acid