Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate

Base Information

Chemical Name:Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate
CAS No.:182137-57-1
Molecular Formula:C₁₂H₂₁NO₃
Molecular Weight:227.304
Hs Code.:
DSSTox Substance ID:DTXSID801141726
Nikkaji Number:J2.472.686J

Synonyms:Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate;182137-57-1;7-Azabicyclo[2.2.1]heptane-7-carboxylic acid, 1-(hydroxymethyl)-, 1,1-dimethylethyl ester;SCHEMBL2125576;SCHEMBL16391848;SCHEMBL24641558;LRNLIMHUUCUPDJ-UHFFFAOYSA-N;DTXSID801141726;CS-0310792;EN300-740216;1,1-Dimethylethyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate;1-(Hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate

Chemical Property:

Boiling Point:318.2±15.0 °C(Predicted)
Density:1.155±0.06 g/cm3(Predicted)
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:227.15214353
Heavy Atom Count:16
Complexity:287

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C2CCC1(CC2)CO

Technology Process of Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate

There total 1 articles about Tert-butyl 1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 182137-51-5
7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

: 182137-57-1
1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: tert-butyl (1s,4s)-1-formyl-7-azabicyclo[2.2.1]heptane-7-carboxylate

: 1-Dihydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1021/jo960759m

Reference yield: 82.0%

: 182137-57-1
1-(hydroxymethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: tert-butyl (1s,4s)-1-formyl-7-azabicyclo[2.2.1]heptane-7-carboxylate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/j.tetlet.2010.10.079