7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

Base Information

Chemical Name:7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester
CAS No.:182137-51-5
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

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Chemical Property of 7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

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Technology Process of 7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

There total 2 articles about 7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182137-41-3
7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]-heptane tert-butyl ester

: 182137-51-5
7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / HCl / H₂O / 25 h / 85 °C

2: 1.) p-TsOH*H₂O, 2.) DIEA / 1.) benzene, reflux, 25 h, 2.) MeOH, 21 h.

With hydrogenchloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In water;
DOI:10.1021/jo960759m

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 7-azabicyclo[2.2.1]heptane-1-carboxylic acid hydrochloride

: 100-51-6,185532-71-2
benzyl alcohol

: 182137-51-5
7-(tert-butyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane benzyl ester

Guidance literature:: With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) benzene, reflux, 25 h, 2.) MeOH, 21 h.;
DOI:10.1021/jo960759m