[(4-Methylphenyl)-phenylmethyl]azanium;chloride

Base Information

• Chemical Name: [(4-Methylphenyl)-phenylmethyl]azanium;chloride
• CAS No.: 5267-49-2
• Molecular Formula: C₁₄H₁₅N*ClH
• Molecular Weight: 233.73654
• Mol file: 5267-49-2.mol

Synonyms:

Chemical Property of [(4-Methylphenyl)-phenylmethyl]azanium;chloride

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 233.0971272
• Heavy Atom Count: 16
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

[(4-methylphenyl)(phenyl)methyl]aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(C2=CC=CC=C2)[NH3+].[Cl-]

Technology Process of [(4-Methylphenyl)-phenylmethyl]azanium;chloride

There total 11 articles about [(4-Methylphenyl)-phenylmethyl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(diphenylmethylene)-1-(4-methylphenyl)-1-phenylmethanamine → (RS)-(4-methylphenyl)phenylmethylamine hydrochloride (5267-49-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c3sc53526f

Reference yield: 73.0%

N-benzylxanthone imine (6229-07-8) + para-chlorotoluene (106-43-4) → (RS)-(4-methylphenyl)phenylmethylamine hydrochloride (5267-49-2)

Guidance literature:

N-benzylxanthone imine; para-chlorotoluene; With bis(η3-allyl-μ-chloropalladium(II)); cesiumhydroxide monohydrate; tricyclohexylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Reflux; Inert atmosphere;

With hydrogenchloride; sodium cyanoborohydride; In ethanol; water; at 25 ℃; for 2h;

With hydrogenchloride; In ethanol; water; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2009.02.034

Reference yield: 60.0%

N-(4-methylphenylmethyl)xanthone imine (1069136-40-8) + chlorobenzene (108-90-7) → (RS)-(4-methylphenyl)phenylmethylamine hydrochloride (5267-49-2)

Guidance literature:

N-(4-methylphenylmethyl)xanthone imine; chlorobenzene; With bis(η3-allyl-μ-chloropalladium(II)); cesiumhydroxide monohydrate; tricyclohexylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Reflux; Inert atmosphere;

With hydrogenchloride; sodium cyanoborohydride; In ethanol; water; at 25 ℃; for 2h;

With hydrogenchloride; In ethanol; water; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2009.02.034

upstream raw materials:

4-Methylbenzophenone

para-bromotoluene

N-(Diethoxyphosphoryl)benzylideneimine

phenyl-p-tolylmethylamine

Downstream raw materials:

(R)-(+)-N-[(4-methylphenyl)(phenyl)methyl]acetamide

(S)-(-)-N-[(4-methylphenyl)(phenyl)methyl]acetamide