4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid

Base Information

• Chemical Name: 4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid
• CAS No.: 116776-52-4
• Molecular Formula: C₁₆H₁₃ClO₃
• Molecular Weight: 288.73
• Hs Code.: 2918300090
• Mol file: 116776-52-4.mol

Synonyms:4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid

Chemical Property of 4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid

Chemical Property:

• PSA: 54.37000
• LogP: 3.78120

Purity/Quality:

≥99% ^*data from raw suppliers

4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid

There total 5 articles about 4-(4-Chlorophenyl)-4-oxo-2-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorophenyl)-4-oxo-2-phenylbutanenitrile (6273-45-6) → 4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid (116776-52-4)

Guidance literature:

With hydrogenchloride; 1) r.t., 2 h, 2) reflux, 3 h;

Reference yield:

methyl 4-oxo-4-(4-chlorophenyl)-2-phenyl-butanoate (6273-34-3) → 4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid (116776-52-4)

Guidance literature:

With potassium hydroxide;

Reference yield:

4'-chlorochalcone (956-02-5) → 4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid (116776-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: alcohol; diluted acetic acid / 35 - 40 °C

2: hydrochloric acid

3: methanolic KOH-solution

With hydrogenchloride; potassium hydroxide; ethanol; acetic acid;

upstream raw materials:

methyl 4-oxo-4-(4-chlorophenyl)-2-phenyl-butanoate

(4-chlorphenyl)magnesium bromide

2-phenylsuccinic anhydride

4-(4-chlorophenyl)-4-oxo-2-phenylbutanenitrile

Downstream raw materials:

4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid ethyl ester

4-(4-chloro-phenyl)-3-hydroxy-4-oxo-2-phenyl-butyric acid

4-[6-(4-Chloro-phenyl)-4-phenyl-pyridazin-3-yl]-morpholine

6-(4-Chloro-phenyl)-4-phenyl-3-piperidin-1-yl-pyridazine

Refernces