6273-34-3

Basic information

• Product Name: methyl 4-(4-chlorophenyl)-4-oxo-2-phenylbutanoate
• CAS NO: 6273-34-3
• Molecular Formula: C₁₇H₁₅ClO₃
• Molecular Weight: 302.7522
• Mol File: 6273-34-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 439.6°C at 760 mmHg
• Flash Point: 170.2°C
• Density: 1.223g/cm³
• Vapor Pressure: 6.32E-08mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: methyl 4-(4-chlorophenyl)-4-oxo-2-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-chlorophenyl)-4-oxo-2-phenylbutanoate(6273-34-3)
• EPA Substance Registry System: methyl 4-(4-chlorophenyl)-4-oxo-2-phenylbutanoate(6273-34-3)

Safety Data

• Hazardous Substances Data: 6273-34-3(Hazardous Substances Data)

Upstream product

• 956-02-5 4'-chlorochalcone 
• 99-91-2 para-chloroacetophenone 
• 67-56-1 methanol 
• 6273-45-6 4-(4-chlorophenyl)-4-oxo-2-phenylbutanenitrile 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 56961-35-4 4-(4-chloro-phenyl)-3-hydroxy-4-oxo-2-phenyl-butyric acid 
• 853996-41-5 3-bromo-4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid 
• 2166-12-3 6-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 116776-52-4 4-(4-chloro-phenyl)-4-oxo-2-phenyl-butyric acid 
• 75616-26-1 6-(4-Chloro-phenyl)-2,4-diphenyl-4,5-dihydro-2H-pyridazin-3-one 
• 75616-30-7 6-(4-Chloro-phenyl)-4-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

New reaction of enamines with aryldiazoacetates catalyzed by transition metal complexes

The reaction of aryldiazoacetates with enamines catalyzed by copper and rhodium complexes provided γ-keto esters in good yields. A full investigation of the effects of solvents, catalysts, enamines and aryldiazoacetates on the reaction was carried out. Careful analysis of the crude reaction mixture revealed a substituted enamine as the primary product, which was hydrolyzed over silica gel to give a γ-keto ester as the final product. A reaction mechanism involving nucleophilic addition of an enamine to a metal carbene and subsequent hydrogen transfer was proposed. Chiral dirhodium and copper catalysts were examined and found to provide γ-keto esters with no enantioselectivity. The result could be rationalized based on the proposed reaction mechanism. Attempts to trap the enamine intermediate with several electrophilic reagents were not successful.

Different Regioselective Behaviour of Organolithium and Organomagnesium Reagents toward Pyridazine Derivatives

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