3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester
• CAS No.: 866807-26-3
• Molecular Formula: C7H7ClN2O2
• Molecular Weight: 186.6
• Hs Code.: 2933399090
• Mol file: 866807-26-3.mol

Synonyms:3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester;Methyl 3-amino-6-chloropicolinate

Chemical Property of 3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester

Chemical Property:

• Boiling Point: 364.7±37.0 °C(Predicted)
• PKA: -0.07±0.10(Predicted)
• PSA: 65.21000
• Density: 1.384±0.06 g/cm3(Predicted)
• LogP: 1.68500

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-amino-6-chloropicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester

There total 5 articles about 3-Amino-6-chloro-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 3-amino-6-chloro-pyridine-2-carboxylic acid (866807-27-4) → methyl 3-amino-6-chloropicolinate (866807-26-3)

Guidance literature:

With thionyl chloride; at 0 - 75 ℃; for 16h;

Reference yield:

3-amino-6-chloro-pyridine-2-carboxylic acid (866807-27-4) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 3-amino-6-chloropicolinate (866807-26-3)

Guidance literature:

In methanol; hexane; toluene; at 20 ℃; for 1.75h;

Reference yield:

6-Chloro-pyridin-3-ylamine (5350-93-6) → methyl 3-amino-6-chloropicolinate (866807-26-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 45.5 h / 20 - 90 °C

3.1: potassium permanganate / water; acetone / 0 - 20 °C

3.2: pH ~ 12

3.3: pH ~ 2

4.1: methanol; hexane; toluene / 1.75 h / 20 °C

With potassium permanganate; N-iodo-succinimide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetone; toluene;

upstream raw materials:

3-amino-6-chloro-pyridine-2-carboxylic acid

diazomethyl-trimethyl-silane

6-Chloro-pyridin-3-ylamine

3-amino-6-chloro-2-(2-furanyl) pyridine

Downstream raw materials:

3-amino-4-bromo-6-chloropyridine-2-carboxylic acid

2,4,6-trichloropyrido[3,2-d]pyrimidine

6-chloropyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

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