6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Base Information

Chemical Name:6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one
CAS No.:1178884-20-2
Molecular Formula:C₃₆H₃₉N₅O₅
Molecular Weight:621.736
Hs Code.:

6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Synonyms:6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

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Chemical Property of 6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

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Technology Process of 6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

There total 15 articles about 6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178884-70-2
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-benzyl ester

: 1178884-20-2
6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With lithium hydrochloride monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 153888-45-0
5-bromo-1-methyl-3-nitropyridine-2(1H)-one

: 1178884-20-2
6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: iron; acetic acid; hydrogenchloride; sodium hydroxide / water; dichloromethane / 2 h / 35 °C / Large scale

2: sodium hydride / toluene; n-heptane; 1-methyl-pyrrolidin-2-one; mineral oil

3: potassium acetate; palladium diacetate; XPhos / 1,4-dioxane / 12 h / 95 - 100 °C / Inert atmosphere

4: potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 2-methyltetrahydrofuran / 12 h / Reflux

With hydrogenchloride; potassium acetate; palladium diacetate; iron; sodium hydride; potassium carbonate; acetic acid; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 2-methyltetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; n-heptane; dichloromethane; water; toluene; mineral oil; 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/op4001077

Reference yield:

: 910543-72-5
3-amino-5-bromo-1-methyl-2H-pyridin-2-one

: 1178884-20-2
6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / toluene; n-heptane; 1-methyl-pyrrolidin-2-one; mineral oil

2: potassium acetate; palladium diacetate; XPhos / 1,4-dioxane / 12 h / 95 - 100 °C / Inert atmosphere

3: potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 2-methyltetrahydrofuran / 12 h / Reflux

With potassium acetate; palladium diacetate; sodium hydride; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 2-methyltetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; n-heptane; toluene; mineral oil; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/op4001077