2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol

Base Information

• Chemical Name: 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol
• CAS No.: 779331-13-4
• Molecular Formula: C13H16BF3O3
• Molecular Weight: 288.074
• Mol file: 779331-13-4.mol

Synonyms:2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol

Chemical Property of 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol

Chemical Property:

• PSA: 38.69000
• LogP: 2.71020

Purity/Quality:

99% ^*data from raw suppliers

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol

There total 6 articles about 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

[2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid (612833-41-7) + 2,3-dimethyl-2,3-butane diol (76-09-5) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol (779331-13-4)

Guidance literature:

[2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid; 2,3-dimethyl-2,3-butane diol; In toluene; Heating / reflux;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 24h;

Reference yield: 63.0%

4,4,5,5-tetramethyl-2-(4-(trifluoromethyl)phenoxy)-1,3,2-dioxaborolane + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol (779331-13-4)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In cyclohexane; at 80 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.7b02232

Reference yield:

C11H15F3OSi + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol (779331-13-4)

Guidance literature:

C₁₁H₁₅F₃OSi; bis(pinacol)diborane; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 20 - 80 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol5031734

upstream raw materials:

[2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid

2,3-dimethyl-2,3-butane diol

4-hydroxybenzotrifluoride

bis(pinacol)diborane

Downstream raw materials:

2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenoxy]-(2S)-propanoic acid 1,1-dimethylethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 779331-13-4 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)phenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send