3,5-Dimethoxy-4-hydroxybenzhydrazide

Base Information

• Chemical Name: 3,5-Dimethoxy-4-hydroxybenzhydrazide
• CAS No.: 1443-76-1
• Molecular Formula: C9H12 N2 O4
• Molecular Weight: 212.205
• Hs Code.: 2928000090
• NSC Number: 77902
• DSSTox Substance ID: DTXSID50162667
• Nikkaji Number: J298.628K
• Wikidata: Q81985461
• Mol file: 1443-76-1.mol

Synonyms:3,5-Dimethoxy-4-hydroxybenzhydrazide;1443-76-1;4-Hydroxy-3,5-dimethoxybenzohydrazide;Benzoic acid, 4-hydroxy-3,5-dimethoxy-, hydrazide;EINECS 215-884-5;4-hydroxy-3,5-dimethoxybenzhydrazide;NSC77902;NCIOpen2_004585;SCHEMBL6530628;DTXSID50162667;MFCD00017077;NSC 77902;NSC-77902;AKOS015851415;SB85959;4-Hydroxy-3,5-dimethoxybenzohydrazide #;AS-68288;CS-0187017;FT-0614636;3,5-DIMETHOXY-4-HYDROXY BENZHYDRAZIDE;4-hydroxy-3,5-dimethoxy-benzoic acid hydrazide;D97316

Chemical Property of 3,5-Dimethoxy-4-hydroxybenzhydrazide

Chemical Property:

• Melting Point: 156-157°C
• Boiling Point: 379.5°Cat760mmHg
• PKA: 8.63±0.25(Predicted)
• Flash Point: 155°C
• PSA: 93.81000
• Density: 1.335g/cm³
• LogP: 1.10410
• XLogP3: 0
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 212.07970687
• Heavy Atom Count: 15
• Complexity: 210

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dimethoxy-4-hydroxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)OC)C(=O)NN

Technology Process of 3,5-Dimethoxy-4-hydroxybenzhydrazide

There total 4 articles about 3,5-Dimethoxy-4-hydroxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,5-dimethoxy-4-hydroxybenzoic acid chloride (50597-60-9) → 4-hydroxy-3,5-dimethoxybenzoic acid hydrazide (1443-76-1)

Guidance literature:

With hydrazine hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.2174/1570180815666180219165119

Reference yield:

4-hydroxy-3,5-dimethoxybenzoic acid ethyl ester (3943-80-4) → 4-hydroxy-3,5-dimethoxybenzoic acid hydrazide (1443-76-1)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1007/BF00908806 DOI:10.1021/ja01618a078

Reference yield:

methyl syringate (884-35-5) → 4-hydroxy-3,5-dimethoxybenzoic acid hydrazide (1443-76-1)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1007/BF00908806

upstream raw materials:

4-hydroxy-3,5-dimethoxybenzoic acid ethyl ester

3,4,5-trimethoxybenzoic acid methyl ester

methyl syringate

3,5-dimethoxy-4-hydroxybenzoic acid chloride