tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
• CAS No.: 1252037-59-4
• Molecular Formula: C₁₈H₂₃N₃O₂
• Molecular Weight: 313.4
• Mol file: 1252037-59-4.mol

Synonyms:tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 13 articles about tert-butyl (2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (1007882-59-8) + phenylboronic acid (98-80-6) → (S)-2-(5-phenyl-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1252037-59-4)

Guidance literature:

With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; palladium diacetate; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere; Glovebox;

DOI:10.1021/jo501326r

Reference yield: 99.0%

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (1007882-59-8) + potassium phenyltrifluoborate → (S)-2-(5-phenyl-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1252037-59-4)

Guidance literature:

With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; palladium diacetate; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere; Glovebox;

DOI:10.1021/jo501326r

Reference yield: 98.0%

(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1007882-04-3) → (S)-2-(5-phenyl-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1252037-59-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

1-chloroacetophenone

α-bromoacetophenone

1-(tert-butyl) 2-(2-oxo-2-phenylethyl) (S)-pyrrolidine-1,2-dicarboxylate

Downstream raw materials:

{(S)-2-methyl-1-[(S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carboline]propyl}carbamic acid methyl ester

(S)-5-phenyl-2-(pyrrolidin-2-yl)-1H-imidazole

3,3-dimethyl-5-oxo-5-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-1-(1-methylcyclopropyl)-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)pentanoic acid

2,2-dimethyl-4-oxo-4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-1-(1-methylcyclopropyl)-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)butanoic acid