methyl 2-bromophenethylcarbamate

Base Information

• Chemical Name: methyl 2-bromophenethylcarbamate
• CAS No.: 1109230-24-1
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.115
• Mol file: 1109230-24-1.mol

Synonyms:methyl 2-bromophenethylcarbamate

Chemical Property of methyl 2-bromophenethylcarbamate

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-bromophenethylcarbamate

There total 2 articles about methyl 2-bromophenethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

2-(2-bromophenyl)ethanamine (65185-58-2) + methyl chloroformate (79-22-1) → methyl 2-(2-bromophenyl)ethylcarbamate (1109230-24-1)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 68.0%

2-(2-bromophenyl)acetonitrile (19472-74-3) + methyl chloroformate (79-22-1) → methyl 2-(2-bromophenyl)ethylcarbamate (1109230-24-1)

Guidance literature:

2-(2-bromophenyl)acetonitrile; methyl chloroformate; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 1.5h;

With diethylamine; In methanol; for 0.5h;

DOI:10.1021/jo102452d

Reference yield: 84.0%

methyl 2-(2-bromophenyl)ethylcarbamate (1109230-24-1) + (S,E)-tert-butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-yl)oxy)silane (1198272-03-5) → (3S)-(E)-N-methoxycarbonyl-N-[2-[2-(3-tert-butyldimethylsilyloxy-1-butenyl)phenyl]ethyl]amine (1273546-94-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In 1,4-dioxane; water; at 80 ℃; for 2h;

DOI:10.1021/jo102452d

upstream raw materials:

2-(2-bromophenyl)ethanamine

methyl chloroformate

2-(2-bromophenyl)acetonitrile

Downstream raw materials:

5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one

(3S)-(E)-N-methoxycarbonyl-N-[2-[2-(3-hydroxy-1-butenyl)phenyl]ethyl]amine

(3S)-(E)-N-methoxycarbonyl-N-[2-[2-(3-tert-butyldimethylsilyloxy-1-butenyl)phenyl]ethyl]amine

tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate