1H-pyrazole-5-carbohydrazide

Base Information

• Chemical Name: 1H-pyrazole-5-carbohydrazide
• CAS No.: 26275-64-9
• Molecular Formula: C4H6N4O
• Molecular Weight: 126.118
• Hs Code.: 2933199090
• European Community (EC) Number: 871-831-1
• DSSTox Substance ID: DTXSID90428077
• Wikidata: Q82240855
• Mol file: 26275-64-9.mol

Synonyms:1H-pyrazole-5-carbohydrazide;26275-64-9;2H-Pyrazole-3-carboxylic acid hydrazide;1H-Pyrazole-3-carbohydrazide;2 h-pyrazole-3-carboxylic acid hydrazide;pyrazole-5-carbohydrazide;aminocarbamoylpyrazole;SCHEMBL298545;DTXSID90428077;VWOQOMNXHWAQMJ-UHFFFAOYSA-N;BBL014144;MFCD00717711;STK281590;AKOS000305715;AKOS003367786;PB12701;AS-50413;CS-0054786;FT-0683596;EN300-228874;P10142;A877287

Chemical Property of 1H-pyrazole-5-carbohydrazide

Chemical Property:

• PSA: 83.80000
• LogP: 0.10440
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 126.05416083
• Heavy Atom Count: 9
• Complexity: 115

Purity/Quality:

98%Min ^*data from raw suppliers

1H-Pyrazole-5-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(NN=C1)C(=O)NN

Technology Process of 1H-pyrazole-5-carbohydrazide

There total 2 articles about 1H-pyrazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 1H-pyrazole 3-carboxylate (15366-34-4) → 1H-pyrazole-3-carbohydrazide (26275-64-9)

Guidance literature:

With hydrazine; In ethanol; water; Heating;

DOI:10.1007/s10593-015-1724-3

Reference yield: 86.0%

methyl 1H-pyrazole-3-carboxylate (15366-34-4) → hydrazide de l'acide pyrazole-carboxylique-5 (26275-64-9)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; Reflux;

Reference yield: 45.0%

benzoyl chloride (98-88-4) + hydrazide de l'acide pyrazole-carboxylique-5 (26275-64-9) → N-benzoylhydrazide de l'acide pyrazole carboxylique-5

Guidance literature:

In pyridine; for 3h; Heating;

upstream raw materials:

methyl 1H-pyrazole 3-carboxylate

methyl 1H-pyrazole-3-carboxylate

Downstream raw materials:

3-phenyl-3-(1⁽²⁾H-pyrazole-3-carbonylhydrazono)-propionic acid ethyl ester

dihydro-1,2 oxo-1 pyrazolo<1,5-d>triazine-1,2,4

orthoformic acid triethyl ester

5-(1(2)H-pyrazol-3-yl)-3H-[1,3,4]oxadiazole-2-thione

Refernces

• 1、 -. "P38 KINASE INHIBITING AGENTS". Page/Page column 56-57. . Retrieved 2010/11/18.