1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-

Base Information

Chemical Name:1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-
CAS No.:1300019-46-8
Molecular Formula:C19H17ClN2O4
Molecular Weight:372.808
Hs Code.:

Synonyms:1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-

Suppliers and Price of 1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-

Chemical Property:

Purity/Quality:: NLT 98% ^*data from raw suppliers

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Technology Process of 1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)-

There total 15 articles about 1H-1,4-Benzodiazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-7-Methoxy-2-oxo-, Methyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1300019-48-0
methyl N¹-[2-[(4-chlorophenyl)carbonyl]-4-(methyloxy)phenyl]-N²-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-L-α-asparaginate

: 1300019-46-8
(S)-methyl 2-(5-(4-chlorophenyl)-7-methoxy-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: methyl N¹-[2-[(4-chlorophenyl)carbonyl]-4-(methyloxy)phenyl]-N²-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-L-α-asparaginate; With triethylamine; In dichloromethane; for 24h; Reflux;

With acetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water; Product distribution / selectivity;

Reference yield: 69.0%

: C₁₉H₁₉ClN₂O₅

: 1300019-46-8
(S)-methyl 2-(5-(4-chlorophenyl)-7-methoxy-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: With acetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 2h;
DOI:10.1021/jm401088k

Reference yield: 30.0%

: 596095-91-9
methyl (3S)-4-chloro-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoate

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

: 1300019-46-8
(S)-methyl 2-(5-(4-chlorophenyl)-7-methoxy-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate

Guidance literature:: methyl (3S)-4-chloro-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoate; [2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone; In chloroform; for 1h; Reflux;

With triethylamine; In chloroform; for 16h; Reflux;
DOI:10.1021/jm200108t