8-Chlorochroman

Base Information

Chemical Name:8-Chlorochroman
CAS No.:3722-69-8
Molecular Formula:C₉H₉ClO
Molecular Weight:168.623
Hs Code.:
DSSTox Substance ID:DTXSID30697780
Nikkaji Number:J3.665.819C
Mol file:3722-69-8.mol

Synonyms:8-Chlorochroman;3722-69-8;8-Chloro-3,4-dihydro-2H-1-benzopyran;8-chloro-3,4-dihydro-2H-chromene;SCHEMBL15319473;DTXSID30697780;CYSQTUPJQFEKES-UHFFFAOYSA-N;MFCD03695452;AKOS006279204;DS-3275;CS-0155312;J3.665.819C;N10904

Suppliers and Price of 8-Chlorochroman

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 8-Chlorochroman

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:168.0341926
Heavy Atom Count:11
Complexity:138

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C(=CC=C2)Cl)OC1

Technology Process of 8-Chlorochroman

There total 6 articles about 8-Chlorochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 2-chloro-6-(3-hydroxypropyl)phenol

: 3722-69-8
8-Chlorchroman

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 15h; Inert atmosphere;

Reference yield:

: 22991-03-3
3-(3-chlorophenyl)propanol

: 3722-71-2
6-chlorochromane

: 3722-69-8
8-Chlorchroman

Guidance literature:: With Co(dmgBF₂)₂(CH₃CN)₂; 3-cyano-N-methyl-quinolinium perchlorate; In acetonitrile; at 20 ℃; Overall yield = 68 %; regioselective reaction; Sealed tube; Inert atmosphere; Irradiation; High pressure;
DOI:10.1021/acs.orglett.7b00463

Reference yield:

: 5348-07-2
2-chloro-6-(prop-2-en-1-yl)phenol

: 3722-69-8
8-Chlorchroman

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 15 h / 20 °C

1.2: 1.75 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere

With borane-THF; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;