5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one

Base Information

Chemical Name:5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one
CAS No.:1272353-85-1
Molecular Formula:C25H19N5O
Molecular Weight:405.459
Hs Code.:
Mol file:1272353-85-1.mol

Synonyms:5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one

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Chemical Property of 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one

Chemical Property:

PSA：83.56000
LogP:4.73220

Purity/Quality:

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Technology Process of 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one

There total 7 articles about 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

: 1272354-52-5
2-(6-methoxypyridin-3-yl)-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272353-85-1
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridin-2(1H)-one

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 18h;
DOI:10.1021/acsmedchemlett.6b00117

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272353-85-1
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: triethylamine / tetrahydrofuran / 14 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 12 h / 90 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 72 h / 0 - 20 °C

With boron tribromide; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272353-85-1
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 12 h / 90 °C / Inert atmosphere

7.1: boron tribromide / dichloromethane / 72 h / 0 - 20 °C

With dihydrogen peroxide; boron tribromide; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;