ML277

Base Information

Chemical Name:ML277
CAS No.:1401242-74-7
Molecular Formula:C23H25N3O4S2
Molecular Weight:471.59
Hs Code.:
Mol file:1401242-74-7.mol

Synonyms:ML277;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;CID-53347902;VU0458298-2, VU0458298-3

Suppliers and Price of ML277

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 277
5mg
$ 355.00

Usbiological
ML 277
10mg
$ 480.00

TRC
ML277
10mg
$ 140.00

Tocris
ML277 ≥98%(HPLC)
10
$ 225.00

Tocris
ML277 ≥98%(HPLC)
50
$ 943.00

DC Chemicals
ML-277 >98%
1 g
$ 2100.00

DC Chemicals
ML-277 >98%
100 mg
$ 550.00

ChemScene
ML277 99.43%
50mg
$ 696.00

ChemScene
ML277 99.43%
5mg
$ 94.00

ChemScene
ML277 99.43%
10mg
$ 170.00

Total 16 raw suppliers

Chemical Property of ML277

Chemical Property:

PKA:8.37±0.70(Predicted)
PSA：128.71000
Density:1.341±0.06 g/cm3(Predicted)
LogP:5.97720
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

ML 277 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Description Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of ML277 at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.
Uses ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

Technology Process of ML277

There total 4 articles about ML277 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₉N₃O₂S

: 98-59-9
p-toluenesulfonyl chloride

: 1401242-74-7
ML₂₇₇

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2012.07.060

Reference yield:

: 28697-17-8
N-BOC-D-pipecolic acid

: 1401242-74-7
ML₂₇₇

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: triethylamine / dichloromethane / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.060

Reference yield:

: 1400283-95-5
C₂₁H₂₇N₃O₄S

: 1401242-74-7
ML₂₇₇

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.07.060