1,3-Dithiolan-2-ylphenylmethanone

Base Information

• Chemical Name: 1,3-Dithiolan-2-ylphenylmethanone
• CAS No.: 21504-08-5
• Molecular Formula: C10H10OS2
• Molecular Weight: 210.321
• Mol file: 21504-08-5.mol

Synonyms:1,3-Dithiolan-2-ylphenyl ketone;1,3-Dithiolan-2-ylphenylmethanone

Chemical Property of 1,3-Dithiolan-2-ylphenylmethanone

Chemical Property:

• Melting Point: 101 - 103 °C
• PSA: 67.67000
• LogP: 2.67540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Dithiolan-2-ylphenylmethanone

There total 3 articles about 1,3-Dithiolan-2-ylphenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-methoxy-N-methyl-1,3-dithiolane-2-carboxamide (942498-70-6) + phenylmagnesium bromide → 2-(benzoyl)-1,3-dithiolane (21504-08-5)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1055/s-2007-973882

Reference yield: 78.0%

N-methoxy-N-methyl-1,3-dithiolane-2-carboxamide (942498-70-6) + phenylmagnesium bromide (100-58-3) → 2-(benzoyl)-1,3-dithiolane (21504-08-5)

Guidance literature:

N-methoxy-N-methyl-1,3-dithiolane-2-carboxamide; phenylmagnesium bromide; In tetrahydrofuran; at 0 - 5 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.03.072

Reference yield:

2-Trimethylsilyloxycarbonyl-1,3-dithiolane (73496-61-4) + benzoyl chloride (98-88-4) → 2-(benzoyl)-1,3-dithiolane (21504-08-5)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo01301a012

upstream raw materials:

2-Trimethylsilyloxycarbonyl-1,3-dithiolane

benzoyl chloride

N-methoxy-N-methyl-1,3-dithiolane-2-carboxamide

phenylmagnesium bromide

Downstream raw materials:

1-Benzyl-2-benzoyl-1,3-dithiolanium triflate

C₁₇H₁₈O₂S₂

2-((4-methoxyphenyl)(phenyl)methyl)-1,3-dithiolane

2-Benzoyl-3,6-dihydro-4,5-dimethyl-2-methylthio-2H-thiopyran

Refernces

• 1、 Balasubramaniam, Sivaraman,Aidhen, Indrapal Singh. "Synthetic equivalents based on Weinreb amide functionality for convenient access to monoprotected α-diketones". . p. 959 - 963. Retrieved 2008/02/02.