H-D-Lys(Z)-OMe . HCl

Base Information

• Chemical Name: H-D-Lys(Z)-OMe . HCl
• CAS No.: 1158-35-6
• Molecular Formula: C15H22N2O4.ClH
• Molecular Weight: 330.812
• Mol file: 1158-35-6.mol

Synonyms:H-D-LYS(Z)-OME HCL

Chemical Property of H-D-Lys(Z)-OMe . HCl

Chemical Property:

• PSA: 94.14000
• LogP: 3.29010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-D-Lys(z)-omeHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-D-Lys(z)-ome Hydrochloride is a useful intermediate used in the preparation of analgesic dipeptide derivatives with analgesic properties.

Technology Process of H-D-Lys(Z)-OMe . HCl

There total 5 articles about H-D-Lys(Z)-OMe . HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + C14H20N2O4*ClH → Nε-benzyloxycarbonyl-D-lysine methyl ester hydrochloride (1158-35-6)

Guidance literature:

With sulfuryl dichloride; at -25 ℃; for 3h;

DOI:10.1039/d0md00033g

Reference yield:

methanol (67-56-1) + (R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid (34404-32-5,1155-64-2,32302-83-3,57705-97-2,67178-46-5,25931-47-9) → Nε-benzyloxycarbonyl-D-lysine methyl ester hydrochloride (1158-35-6)

Guidance literature:

With hydrogenchloride; at 25 ℃; for 6h;

Reference yield:

C12H26CuN4O4 → Nε-benzyloxycarbonyl-D-lysine methyl ester hydrochloride (1158-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water / 12 h / 25 °C

2: EDTA SS / 24 h / 25 °C

3: hydrogenchloride / 6 h / 25 °C

With hydrogenchloride; sodium hydrogencarbonate; In water;

upstream raw materials:

methanol

(R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid

benzyl chloroformate

Refernces

• 1、 Antwi, Isaac,Chiorean, Sorina,Van Belkum, Marco J.,Vederas, John C.. "Unveiling the active isomer of cycloalanopine, a cyclic opine from: Lactobacillus rhamnosus LS8, through synthesis and analog production". supporting information. p. 528 - 531. Retrieved 2020/05/13.
• 2、 Wang, Qiang,Shi, Qiao,Huang, Lu. "Novel aminopeptidase n inhibitors with improved antitumor activities". . p. 98 - 106. Retrieved 2015/12/01.