Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester

Base Information

• Chemical Name: Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester
• CAS No.: 1420623-75-1
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18666
• Mol file: 1420623-75-1.mol

Synonyms:Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester;IMidazo[1,2-b]pyridazine-3-carboxylic acid, ethyl ester

Chemical Property of Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester

Chemical Property:

• PSA: 56.49000
• LogP: 0.90600

Purity/Quality:

97% ^*data from raw suppliers

Ethylimidazo[1,2-b]pyridazine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester

There total 4 articles about Ethyl iMidazo[1,2-b]pyridazine-3-carboxylic ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 2-bromo-3-(dimethylamino)-3-(pyridazin-3-ylamino)propanoate (1428929-48-9) → ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1420623-75-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 4h;

Reference yield: 73.0%

6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1150566-27-0) → ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1420623-75-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1016/j.ejmech.2021.113298

Reference yield: 40.8%

3-aminopyridazine (5469-70-5) + ethyl 2-chloro-3-oxopropanoate (33142-21-1) → ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1420623-75-1)

Guidance literature:

In ethanol; Reflux;

upstream raw materials:

3-aminopyridazine

ethyl 2-chloro-3-oxopropanoate

N,N-dimethyl-N'-pyridazin-3-yl-formamidine

ethyl 2-bromo-3-(dimethylamino)-3-(pyridazin-3-ylamino)propanoate

Downstream raw materials:

imidazo[1,2-b]pyridazine-3-carbaldehyde

C₂₄H₂₀ClN₅O

imidazo[1,2-b]pyridazine-3-carboxylic acid

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