IMidazo[1,2-b]pyridazine-3-carboxylic acid

Base Information

• Chemical Name: IMidazo[1,2-b]pyridazine-3-carboxylic acid
• CAS No.: 1308384-58-8
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.136
• Mol file: 1308384-58-8.mol

Synonyms:IMidazo[1,2-b]pyridazine-3-carboxylic acid

Chemical Property of IMidazo[1,2-b]pyridazine-3-carboxylic acid

Chemical Property:

• PKA: 6.06±0.30(Predicted)
• PSA: 67.49000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: 0.42750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

imidazo[1,2-b]pyridazine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of IMidazo[1,2-b]pyridazine-3-carboxylic acid

There total 3 articles about IMidazo[1,2-b]pyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1420623-75-1) → imidazo[1,2-b]pyridazine-3-carboxylic acid (1308384-58-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.ejmech.2021.113298

Reference yield:

6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1150566-27-0) → imidazo[1,2-b]pyridazine-3-carboxylic acid (1308384-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol / 20 °C / 760.05 Torr

2: lithium hydroxide monohydrate / water; methanol; tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2021.113298

Reference yield:

→ imidazo[1,2-b]pyridazine-3-carboxylic acid (1308384-58-8)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 20h; Reflux;

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

ethyl imidazo[1,2-b]pyridazine-3-carboxylate

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