(2-Methyloxazol-5-yl)Methanol

Base Information

• Chemical Name: (2-Methyloxazol-5-yl)Methanol
• CAS No.: 1065073-48-4
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.11458
• Hs Code.: 2934999090
• Mol file: 1065073-48-4.mol

Synonyms:(2-Methyloxazol-5-yl)Methanol

Chemical Property of (2-Methyloxazol-5-yl)Methanol

Chemical Property:

• Boiling Point: 208.1±15.0 °C(Predicted)
• PKA: 13.43±0.10(Predicted)
• PSA: 46.26000
• Density: 1.183±0.06 g/cm3(Predicted)
• LogP: 0.47530

Purity/Quality:

98%min ^*data from raw suppliers

(2-Methyl-oxazol-5-yl)-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Methyloxazol-5-yl)Methanol

There total 4 articles about (2-Methyloxazol-5-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-methyloxazole-5-carboxylic acid methyl ester (651059-70-0) → (2-methyl-1,3-oxazol-5-yl)methanol (1065073-48-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - -40 ℃; for 3h;

Reference yield:

ethyl 2-methyloxazole-4-carboxylate (76284-27-0) → (2-methyl-1,3-oxazol-5-yl)methanol (1065073-48-4)

Guidance literature:

ethyl 2-methyloxazole-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran; for 1h;

Reference yield:

2-methyl-1,3-oxazole-5-carboxylic acid (1216012-87-1) → (2-methyl-1,3-oxazol-5-yl)methanol (1065073-48-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

upstream raw materials:

ethyl 2-methyloxazole-4-carboxylate

2-methyl-1,3-oxazole-5-carboxylic acid

2-methyloxazole-5-carboxylic acid methyl ester

Downstream raw materials:

C₂₈H₂₄FN₃O₅*ClH

Refernces

• 1、 -. "TETRAHYDRO-IMIDAZO QUINOLINE COMPOSITIONS AS CBP/P300 INHIBITORS". Paragraph 0092. . Retrieved 2019/04/11.
• 2、 -. "SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS". Page/Page column 93. . Retrieved 2013/09/12.