76284-27-0

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl-4-methyl-3,5-oxazolecarboxylate is used as a building block for the production of various drugs and agrochemicals. Its versatile reactivity and functional group compatibility make it a valuable component in the synthesis of a wide range of medicinal compounds.
Used in Flavoring Agent:
In the food industry, Ethyl-4-methyl-3,5-oxazolecarboxylate is used as a flavoring agent, contributing to the taste and aroma of various food products.
Used as an Intermediate in Organic Synthesis:
Ethyl-4-methyl-3,5-oxazolecarboxylate also serves as an intermediate in the synthesis of other organic compounds, further expanding its applications across different chemical industries.

Upstream product

• 14214-10-9 ethyl diazopyruvate 
• 75-05-8 acetonitrile 
• 174902-47-7 Ethyl 2-acetyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 60-35-5 acetamide 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 1065073-48-4 (2-methyl-1,3-oxazol-5-yl)methanol 
• 1569070-26-3 C₂₈H₂₄FN₃O₅*ClH 

Relevant academic research and scientific papers

SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Chemistry of 5-oxodihydroisoxazoles. Part 18. Synthesis of oxazoles by the photolysis and pyrolysis of 2-acyl-5-oxo-2,5-dihydroisoxazoles

N-Acylisoxazol-5-ones lose carbon dioxide under photochemical and thermal conditions affording iminocarbenes which undergo intramolecular cyclisation through the oxygen of the acyl group to give oxazoles. Under photochemical conditions those acylisoxazolones with electron withdrawing groups at C-4 usually give high yields of oxazoles, while those with electron donating groups at C-4 give only poor yields: the reverse is observed under thermal conditions.

The synthesis of oxazoles by thermolysis or photolysis of 2-acylisoxazol-5-ones

N-acylisoxazol-5-ones are converted into the corresponding 2-substituted oxazoles by photolysis at 300 or 254 nm, or by flash vacuum pyrolysis. The former procedure is favoured for isoxazolones with electron withdrawing groups at C-4, and pyrolysis for all others.

The Syntheses of Ethoxycarbonyl-1,3-dioxoles and Oxazoles from the Copper Catalyzad Thermolysis of Ethyl Diazopyruvate in the Presence of Ketones, Aldehydes and Nitriles

The copper salt-catalyzed interaction of ethyl diazopyruvate with ketones, aldehydes and nitriles was examined.A variety of 1,3-dioxoles and oxazoles was obtained in moderate yield.The formation of enol ethers, epoxides, carbon-carbon insertion products, aziridines, and azetidines, typical products of carbene reactions with carbon-heteroatom multiple bonds, was not observed.Evidence for the operation of a 1,3-dipolar cycloaddition reaction is presented.