Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)-

Base Information

• Chemical Name: Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)-
• CAS No.: 112245-04-2
• Molecular Formula: C12H22O4
• Molecular Weight: 230.304
• Mol file: 112245-04-2.mol

Synonyms:Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)-;(2R)-4-methyl-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]pentanoic acid;(2R)-2-[(tert-Butoxycarbonyl)methyl]-4-(methyl)pentanoic acid;(R)-2-(2-(tert-Butoxy)-2-oxoethyl)-4-methylpentanoic acid

Chemical Property of Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)-

Chemical Property:

• Boiling Point: 324.7±25.0 °C(Predicted)
• PKA: 4.50±0.23(Predicted)
• PSA: 63.60000
• Density: 1.021±0.06 g/cm3(Predicted)
• LogP: 2.46510
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(2-(Tert-Butoxy)-2-oxoethyl)-4-methylpentanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)-

There total 16 articles about Butanedioic acid, 2-(2-Methylpropyl)-, 4-(1,1-diMethylethyl) ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2)

Guidance literature:

Reference yield: 91.0%

→ 2-bromo-6-methylphenol (13319-71-6) + (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2)

Guidance literature:

Reference yield: 87.0%

(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5-methylhexanoate (144287-83-2) → (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2)

Guidance literature:

(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5-methylhexanoate; With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;

With lithium hydroxide; In tetrahydrofuran; water; for 2h;

DOI:10.1021/ja403523p

upstream raw materials:

2-(tert-butoxycarbonyl)-(3R)-3-isobutylsuccinic acid

(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5-methylhexanoate

bromoacetic acid tert-butyl ester

(S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one

Downstream raw materials:

2S-isobutyl-3S-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

2S-isobutyl-3-(4-(methylsulfonyl)phenylthio)butan-1,4-dioic acid 4-tert-butyl ester