3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

Base Information

Chemical Name:3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester
CAS No.:198421-66-8
Molecular Formula:C₁₉H₂₅NO₄S
Molecular Weight:363.478
Hs Code.:

Synonyms:3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

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Chemical Property of 3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

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Technology Process of 3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

There total 1 articles about 3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 6339-51-1
bis(4-cyanophenyl)disulfane

: 112245-04-2
(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid

: 198421-66-8
3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

: 3R-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

Guidance literature:: (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;

bis(4-cyanophenyl)disulfane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm990377j

Reference yield: 74.0%

: 89226-12-0
(S)-2-amino-N,3,3-trimethylbutanamide

: 198421-66-8
3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

: 198421-68-0
N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990377j

Reference yield:

: 198421-66-8
3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

: 252670-72-7
N²-[3S-(4-cyanophenylthio)-4-hydroxy-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / HOBT; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / dimethylformamide / 20 °C

2: 77 percent / TFA / CH₂Cl₂ / 18 h / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: acidolysis;
DOI:10.1021/jm990377j