2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

Base Information

• Chemical Name: 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester
• CAS No.: 198421-44-2
• Molecular Formula: C₁₈H₂₆O₄S
• Molecular Weight: 338.468
• Mol file: 198421-44-2.mol

Synonyms:2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

Chemical Property of 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester

There total 1 articles about 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

diphenyldisulfane (882-33-7) + (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2) → 2S-isobutyl-3S-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester (198421-43-1) + 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester (198421-44-2)

Guidance literature:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

diphenyldisulfane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h;

DOI:10.1021/jm990377j

Reference yield: 100.0%

2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester (198421-44-2) → (3S,4R)-3-Isobutyl-4-phenylsulfanyl-dihydro-furan-2,5-dione

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm990377j

Reference yield: 78.0%

(S)-2-amino-N,3,3-trimethylbutanamide (89226-12-0) + 2S-isobutyl-3R-phenylthiobutan-1,4-dioic acid 4-tert-butyl ester (198421-44-2) → N2-[4-tert-butyloxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N1-methylamide (198421-46-4)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990377j

upstream raw materials:

diphenyldisulfane

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid

Downstream raw materials:

N²-[4-tert-butyloxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide

N²-[4-hydroxy-2S-isobutyl-3R-phenylthiosuccinyl]-L-tert-leucine-N¹-methylamide