2-(Benzylthio)phenol

Base Information

• Chemical Name: 2-(Benzylthio)phenol
• CAS No.: 24312-63-8
• Molecular Formula: C13H12OS
• Molecular Weight: 216.304
• Mol file: 24312-63-8.mol

Synonyms:2-(Benzylthio)phenol

Chemical Property of 2-(Benzylthio)phenol

Chemical Property:

• PSA: 45.53000
• LogP: 3.68450

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Benzylthio)phenol

There total 5 articles about 2-(Benzylthio)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ortho-mercaptophenol (1121-24-0) + benzyl bromide (100-39-0) → 2-benzylsulfanyl-phenol (24312-63-8)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.5b01963

Reference yield: 92.0%

2-hydroxybromobenzene (95-56-7) + benzyl bromide (100-39-0) → 2-benzylsulfanyl-phenol (24312-63-8)

Guidance literature:

2-hydroxybromobenzene; With tert.-butyl lithium; isopropylmagnesium chloride; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

benzyl bromide; With sulfur; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2006.07.056

Reference yield: 79.0%

dibenzyl disulphide (150-60-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-benzylsulfanyl-phenol (24312-63-8)

Guidance literature:

With N-Bromosuccinimide; iodine; oxygen; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Reagent/catalyst; Sealed tube;

DOI:10.1002/adsc.201300493

upstream raw materials:

ortho-mercaptophenol

benzyl bromide

benzyl chloride

2-hydroxybromobenzene

Downstream raw materials:

(2-benzylsulfanyl-phenoxy)-acetic acid methyl ester

(2-{[(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)amino]sulfonyl}phenoxy)acetic acid

2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

(2-chlorosulfonyl-phenoxy)-acetic acid methyl ester

Refernces

• 1、 Li, Zheng-Zheng,Wen, A-Hao,Yao, Su-Yang,Ye, Bao-Hui. "Enantioselective syntheses of sulfoxides in octahedral ruthenium(II) complexes via a chiral-at-metal strategy". supporting information. p. 2726 - 2733. Retrieved 2015/03/30.
• 2、 Li, Yiming,Pu, Jiahua,Jiang, Xuefeng. "A highly efficient Cu-catalyzed S-transfer reaction: From amine to sulfide". supporting information. p. 2692 - 2695. Retrieved 2014/06/09.