ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Base Information

• Chemical Name: ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
• CAS No.: 1354822-87-9
• Molecular Formula: C₁₈H₁₉N₃O₂
• Molecular Weight: 309.368
• Mol file: 1354822-87-9.mol

Synonyms:ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Chemical Property of ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

There total 3 articles about ethyl 1-isopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ ethyl 1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (1354822-87-9)

Guidance literature:

In benzene; at 62 ℃;

Reference yield:

acetophenone (98-86-2) → ethyl 1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (1354822-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 0.25 h / 0 °C / Inert atmosphere

1.2: 12 h / 21 °C / Inert atmosphere

2.1: acetic acid / 4.25 h / 21 °C / Inert atmosphere; Reflux

With potassium tert-butylate; acetic acid; In toluene; 1.1: |Claisen Condensation / 1.2: |Claisen Condensation;

DOI:10.1021/acs.jmedchem.7b01863

Reference yield:

potassium salt of ethyl 2-hydroxy-4-oxo-4-phenyl-2-butenoate + 1-(1-methylethyl)-1H-pyrazol-5-amine (3524-16-1) → ethyl 1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (1354822-87-9)

Guidance literature:

With acetic acid; at 21 ℃; for 4.25h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b01863

upstream raw materials:

1-(1-methylethyl)-1H-pyrazol-5-amine

acetophenone

Downstream raw materials:

3-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

ethyl 3-bromo-1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

3-bromo-1-(1-methylethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-6-(2-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide