ethyl 2-(5-chloropyridin-2-yl)acetate

Base Information

• Chemical Name: ethyl 2-(5-chloropyridin-2-yl)acetate
• CAS No.: 1060814-82-5
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.6342
• Mol file: 1060814-82-5.mol

Synonyms:ethyl 2-(5-chloropyridin-2-yl)acetate

Chemical Property of ethyl 2-(5-chloropyridin-2-yl)acetate

Chemical Property:

• PSA: 39.19000
• LogP: 1.84060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl(5-Chloropyridin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(5-chloropyridin-2-yl)acetate

There total 2 articles about ethyl 2-(5-chloropyridin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-Bromo-5-chloro-pyridine (40473-01-6) + diethyl malonate (105-53-3) → ethyl 2-(5-chloropyridin-2-yl)acetate (1060814-82-5)

Guidance literature:

With 2-Picolinic acid; copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 130 ℃; for 24h;

Reference yield: 22.0%

2-methyl-5-chloropyridine (72093-07-3) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-(5-chloropyridin-2-yl)acetate (1060814-82-5)

Guidance literature:

2-methyl-5-chloropyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

Diethyl carbonate; In tetrahydrofuran; hexane; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03667

Reference yield: 80.0%

ethyl 2-(5-chloropyridin-2-yl)acetate (1060814-82-5) + benzylamine (100-46-9) → ethyl 6-methyl-3-phenylimidazo[1,5-a]pyridine-1-carboxylate

Guidance literature:

With sulfur; In dimethyl sulfoxide; at 110 ℃; for 2h; Sealed tube;

DOI:10.1039/c8ob01391h

upstream raw materials:

2-Bromo-5-chloro-pyridine

diethyl malonate

2-methyl-5-chloropyridine

Diethyl carbonate

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