2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE

Base Information

• Chemical Name: 2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE
• CAS No.: 385442-12-6
• Molecular Formula: C10H9FN2
• Molecular Weight: 0
• Mol file: 385442-12-6.mol

Synonyms:2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE

Chemical Property of 2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE

Chemical Property:

• PSA: 17.82000
• LogP: 2.22620

Purity/Quality:

2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE

There total 3 articles about 2-(4-FLUORO-PHENYL)-1-METHYL-1H-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-methyl-1H-imidazole (616-47-7) + 1-Chloro-4-fluorobenzene (352-33-0) → 2-(4-fluorophenyl)-1-methyl-1H-imidazole (385442-12-6)

Guidance literature:

With NHC-Pd(II)-Im; potassium tert-butylate; In water; toluene; at 140 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo5010058

Reference yield: 83.0%

4-fluoro-1-iodobenzene (352-34-1) + C4H5ClMgN2 → 2-(4-fluorophenyl)-1-methyl-1H-imidazole (385442-12-6)

Guidance literature:

4-fluoro-1-iodobenzene; With TurboGrignard; In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

With tbepc; In tetrahydrofuran; at -40 - 0 ℃; for 2h; Inert atmosphere;

C₄H₅ClMgN₂; Further stages;

DOI:10.1039/c4cc08494b

Reference yield: 70.0%

4-fluoro-1-iodobenzene (352-34-1) + 1-methyl-2-tributylstannanyl-1H-imidazole (105494-69-7) → 2-(4-fluorophenyl)-1-methyl-1H-imidazole (385442-12-6)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 50 ℃; for 96h;

DOI:10.1016/S0022-328X(01)00868-3

upstream raw materials:

4-fluoro-1-iodobenzene

1-methyl-2-tributylstannanyl-1H-imidazole

1-methyl-1H-imidazole

1-Chloro-4-fluorobenzene

Downstream raw materials:

2-(4-diphenylphosphanyl-phenyl)-1-methyl-1H-imidazole

Refernces

• 1、 Gu, Zheng-Song,Chen, Wen-Xin,Shao, Li-Xiong. "N -heterocyclic carbene-palladium(II)-1-methylimidazole complex-catalyzed direct C-H bond arylation of (Benz)imidazoles with aryl chlorides". . p. 5806 - 5811. Retrieved 2014/07/08.