(5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester
• CAS No.: 1187222-00-9
• Molecular Formula: C₁₀H₁₄ClN₃O₂
• Molecular Weight: 243.693
• Mol file: 1187222-00-9.mol

Synonyms:(5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester;N-[(6-chloro-2-pyrazinyl)Methyl]-

Chemical Property of (5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Chemical Property:

• Boiling Point: 361.2±42.0 °C(Predicted)
• PKA: 10.53±0.46(Predicted)
• PSA: 74.94000
• Density: 1.224±0.06 g/cm3(Predicted)
• LogP: 1.93450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((6-chloropyrazin-2-yl)methyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

There total 3 articles about (5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-chloropyrazine-2-carbonitrile (6863-74-7) → tert-butyl ((6-chloropyrazin-2-yl)methyl)carbamate (1187222-00-9)

Guidance literature:

With hydrogen; nickel; In ethanol; for 18h;

Reference yield:

pyrazinamide (98-96-4) → tert-butyl ((6-chloropyrazin-2-yl)methyl)carbamate (1187222-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid; dihydrogen peroxide / 40 - 45 °C

2: phosphorus pentachloride / 3.5 h / 95 °C

3: hydrogen / nickel / ethanol / 18 h

With formic acid; phosphorus pentachloride; hydrogen; dihydrogen peroxide; nickel; In ethanol;

Reference yield:

2-pyrazinecarboxamide-4-oxide (768-36-5) → tert-butyl ((6-chloropyrazin-2-yl)methyl)carbamate (1187222-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride / 3.5 h / 95 °C

2: hydrogen / nickel / ethanol / 18 h

With phosphorus pentachloride; hydrogen; nickel; In ethanol;

upstream raw materials:

di-tert-butyl dicarbonate

6-chloropyrazine-2-carbonitrile

pyrazinamide

2-pyrazinecarboxamide-4-oxide

Downstream raw materials:

C-(6-methoxypyrazin-2-yl)methylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1187222-00-9 (5-Hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send