6863-74-7 Usage
Description
6-Chloropyrazine-2-carbonitrile, a chlorinated pyrazine derivative with the chemical formula C5H2ClN3, is a white to off-white solid that is sparingly soluble in water but soluble in organic solvents. It is commonly used as an intermediate in the synthesis of various pharmaceutical and agrochemical products due to its potential biological activities, including as an anticancer and antibacterial agent. However, it is important to handle this chemical with care, as it may pose hazards to human health and the environment.
Uses
Used in Pharmaceutical Industry:
6-Chloropyrazine-2-carbonitrile is used as a key intermediate in the synthesis of various drugs for its potential biological activities. It plays a crucial role in the development of new pharmaceutical compounds with improved therapeutic properties.
Used in Agrochemical Industry:
6-Chloropyrazine-2-carbonitrile is used as a building block in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products helps enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used in Anticancer Research:
6-Chloropyrazine-2-carbonitrile is studied for its potential as an anticancer agent. Its biological activities are being investigated for their ability to target and inhibit the growth of cancer cells, offering a promising avenue for the development of novel cancer therapies.
Used in Antibacterial Applications:
6-Chloropyrazine-2-carbonitrile has been studied for its potential antibacterial properties. It may be used in the development of new antibiotics to combat drug-resistant bacterial strains, thereby addressing the growing global concern of antibiotic resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 6863-74-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,6 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6863-74:
(6*6)+(5*8)+(4*6)+(3*3)+(2*7)+(1*4)=127
127 % 10 = 7
So 6863-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H2ClN3/c6-5-3-8-2-4(1-7)9-5/h2-3H
6863-74-7Relevant articles and documents
Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution
Zitko, Jan,Paterova, Pavla,Kubicek, Vladimir,Mandikova, Jana,Trejtnar, Frantisek,Kunes, Jiri,Dolezal, Martin
, p. 476 - 479 (2013/02/23)
A series of 19 new compounds related to pyrazinamide were synthesized, characterized with analytical data and screened for in vitro whole cell antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium kansasii and two types of Mycobacterium avium. The series consisted of 3-(benzylamino)-5-cyanopyrazine-2-carboxamides and 3-(benzylamino)pyrazine-2,5-dicarbonitriles with various substituents on the phenyl ring. RP-HPLC method was used to determine the lipophilicity of the prepared compounds. Nine compounds exerted similar or better activity against Mycobacterium tuberculosis compared to pyrazinamide (MIC = 6.25-12.5 μg/mL). 3-(Benzylamino)pyrazine-2,5-dicarbonitrile inhibited all of the tested mycobacterial strains with MIC within the range 12.5-25 μg/mL. Although not the most active, 4-NH2 substituted compounds possessed the lowest in vitro cytotoxicity (hepatotoxicity), leading to selectivity index SI = 5.5 and SI >21.
Synthesis, antimycobacterial and antifungal evaluation of 3-arylaminopyrazine-2,5-dicarbonitriles
Palek, Lukas,Dvorak, Jaroslav,Svobodova, Michaela,Buchta, Vladimir,Jampilek, Josef,Dolezal, Martin
, p. 61 - 65 (2008/12/20)
This paper describes preparation and biological evaluation of pyrazinamide analogues. Pyrazinamide with its simple structure gives a good opportunity for further modification regarding an increase of its antimycobacterial activity. We prepared a series of compounds derived from pyrazine-2,5-dicarbonitrile with arylamino substitution in position 3. All compounds were assayed in vitro against major Mycobacterium and various Fungi species. The best activity was found in 3-{[3-(trifluoromethyl)phenyl]amino}pyrazine-2,5-dicarbonitrile 11 with the value of 6.25 μmol-1 against M. tuberculosis H37Rv and moderate activity against minor Mycobacterium pathogens.