4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

Base Information

Chemical Name:4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide
CAS No.:1272353-89-5
Molecular Formula:C₂₆H₂₀N₆O
Molecular Weight:432.484
Hs Code.:
Mol file:1272353-89-5.mol

Synonyms:4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

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Chemical Property of 4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

Chemical Property:

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Technology Process of 4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

There total 10 articles about 4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272356-81-6
4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzoic acid

: 1272353-89-5
4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1272353-89-5
4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 12 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h

3: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 12 h / 110 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 45 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / N,N-dimethyl-formamide / 12 h / 20 °C

With sulfuric acid; water; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272353-89-5
4-((5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-ylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 12 h / 110 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 45 °C

6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / N,N-dimethyl-formamide / 12 h / 20 °C

With water; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;