Tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate

Base Information

• Chemical Name: Tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate
• CAS No.: 203321-83-9
• Molecular Formula: C11H16N2O3
• Molecular Weight: 224.26
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40598259
• Wikidata: Q82493995
• Mol file: 203321-83-9.mol

Synonyms:203321-83-9;tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate;TERT-BUTYL 6-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE;(6-hydroxymethyl-pyridin-2-yl)-carbamic acid tert-butyl ester;tert-butyl N-[6-(hydroxymethyl)pyridin-2-yl]carbamate;TERT-BUTYL [6-(HYDROXYMETHYL)PYRIDIN-2-YL]CARBAMATE;tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate;tert-butyl(6-(hydroxymethyl)pyridin-2-yl)carbamate;tert-butyl[6-(hydroxymethyl)pyridin-2-yl]carbamate;SCHEMBL465792;DTXSID40598259;RCLIUAJKGDHJMP-UHFFFAOYSA-N;MFCD09863092;AKOS005266584;Carbamic acid, [6-(hydroxymethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester;SB35183;AM100477;BS-44271;DA-08453;CS-0273190;G11211;EN300-1225124;W-205991;F1967-3114;(6-Hydroxymethyl-pyridin-2-yl)-carbamic acid t-butyl ester;(6-Hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester;(6-(hydroxymethyl)pyridin-2-yl)-carbamic acid tert-butyl ester;Carbamic acid, N-[6-(hydroxymethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester

Chemical Property of Tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate

Chemical Property:

• PSA: 74.94000
• LogP: 1.93450
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 224.11609238
• Heavy Atom Count: 16
• Complexity: 238

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(6-(hydroxymethyl)pyridin-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=CC=CC(=N1)CO

Technology Process of Tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate

There total 22 articles about Tert-butyl (6-(hydroxymethyl)pyridin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(6-formylpyridin-2-yl)carbamic acid tert-butyl ester → tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate (203321-83-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1002/anie.201411232

Reference yield: 99.0%

6-(N,N-bis(tert-butyloxycarbonyl)amino)picolinic acid ethyl ester (1219130-09-2) → tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate (203321-83-9)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In ethanol; at 0 - 20 ℃; for 3.33333h;

DOI:10.1080/00397911.2011.625291

Reference yield: 95.0%

6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester (203321-86-2) → tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate (203321-83-9)

Guidance literature:

6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester; With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2h;

With water; In ethanol;

upstream raw materials:

6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

6-ethoxycarbonyl-2-pyridinecarboxylic acid

methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate

ethyl 6-aminopicolinate

Downstream raw materials:

4-tert-butoxycarbonylamino-1-(6-tert-butoxycarbonylaminopyridin-2-ylmethyl)piperidine

tert-butyl (2-cyclohexylethyl)[6-(hydroxymethyl)pyridin-2-yl]carbamate

tert-butyl (6-{[({[3-(methoxymethyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)carbamate

tert-butyl (6-(bromomethyl)pyridin-2-yl)carbamate