6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2PYRIDINECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2PYRIDINECARBOXYLIC ACID METHYL ESTER
• CAS No.: 258497-48-2
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.27
• Hs Code.: 2933399090
• Mol file: 258497-48-2.mol

Synonyms:Methyl6-[(tert-butoxycarbonyl)amino]pyridine-2-carboxylate

Chemical Property of 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2PYRIDINECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 3.07E-07mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 419.3°Cat760mmHg
• Flash Point: 207.4°C
• PSA: 77.52000
• Density: 1.149g/cm³
• LogP: 2.28820
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-((tert-butoxycarbonyl)amino)picolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2PYRIDINECARBOXYLIC ACID METHYL ESTER

There total 7 articles about 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2PYRIDINECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 6-aminopyridine-2-carboxylate (36052-26-3) + di-tert-butyl dicarbonate (24424-99-5) → methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate (258497-48-2)

Guidance literature:

With dmap; In tetrahydrofuran; at 60 ℃; for 6h;

Reference yield:

6-[(tert-butoxycarbonyl)amino]-2-pyridinecarboxylic acid (258497-21-1) → methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate (258497-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / dimethylformamide; ethyl acetate

With trichlorophosphate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00603-X

Reference yield:

6-(methoxycarbonyl)pyridine-2-carboxylic acid (7170-36-7) + tert-butyl alcohol (75-65-0) → methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate (258497-48-2)

Guidance literature:

With diphenyl phosphoryl azide; benzotriazol-1-ol; triethylamine; In toluene; at 100 ℃;

upstream raw materials:

methanol

Pyridine-2,6-dicarboxylic acid

6-[(tert-butoxycarbonyl)amino]-2-pyridinecarboxylic acid

6-(methoxycarbonyl)pyridine-2-carboxylic acid

Downstream raw materials:

tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate

(6-(methylamino)pyrid-2-yl)methanol

tert-butyl (6-(bromomethyl)pyridin-2-yl)carbamate

3-[4-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-[1,2,3]thiadiazol-5-ylsulfanyl]-7-[2-(6-tert-butoxycarbonylamino-pyridin-2-yl)-2-trityloxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester