BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE

Base Information

• Chemical Name: BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE
• CAS No.: 916831-70-4
• Molecular Formula: C13H19N3O2.2ClH
• Molecular Weight: 322.234
• Mol file: 916831-70-4.mol

Synonyms:BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE;Piperidine-1-carboxylic acid, 4-hydrazinyl-, phenylMethyl ester, dihydrochloride;4-Hydrazino-piperidine-1-carboxylic acid benzyl ester dihydrochloride;Benzyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride;4-Hydrazinyl-1-piperidinecarboxylic acid phenylmethyl ester hydrochloride (1:1);4-Hydrazino-piperidine-1-carboxylic acid benzyl ester hydrochloride

Chemical Property of BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE

Chemical Property:

• PSA: 67.59000
• LogP: 3.08200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Benzyl4-hydrazinylpiperidine-1-carboxylatedihydrochloride 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE

There total 2 articles about BENZYL 4-HYDRAZINYLPIPERIDINE-1-CARBOXYLATE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate (280111-50-4) → 2-(1-((benzyloxy)carbonyl)piperidin-4-yl)hydrazin-1-ium chloride (916831-70-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 48h;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 2-(1-((benzyloxy)carbonyl)piperidin-4-yl)hydrazin-1-ium chloride (916831-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3 h / Reflux

1.2: 16 h / 20 °C

2.1: hydrogenchloride; methanol / 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; methanol; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 38.0%

2-(1-((benzyloxy)carbonyl)piperidin-4-yl)hydrazin-1-ium chloride (916831-70-4) + ethyl 4,4,4-trifluoro-3-oxobutanimidate → benzyl 4-(5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:

With triethylamine; In ethanol; Reflux;

upstream raw materials:

benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

methyl 1-(1-benzyloxycarbonylpiperidin-4-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylate