tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Base Information

• Chemical Name: tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate
• CAS No.: 1352926-03-4
• Molecular Formula: C₂₀H₃₀N₂O₃
• Molecular Weight: 346.47
• Mol file: 1352926-03-4.mol

Synonyms:tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Chemical Property of tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Chemical Property:

• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

There total 5 articles about tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester (930785-40-3) + benzaldehyde (100-52-7) → tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (1352926-03-4)

Guidance literature:

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; benzaldehyde; With acetic acid; In tetrahydrofuran; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

tert-butyl 4-{[(chloroacetyl)amino]methyl}-4-hydroxypiperidine-1-carboxylate → tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (1352926-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 20 °C / Reflux

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 55 °C

2.2: Reflux

3.1: acetic acid / tetrahydrofuran / 0.25 h / 20 °C

3.2: 20 °C

With dimethylsulfide borane complex; potassium tert-butylate; acetic acid; In tetrahydrofuran; tert-butyl alcohol;

Reference yield:

tert-butyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (1160247-07-3) → tert-butyl 4-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (1352926-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 55 °C

1.2: Reflux

2.1: acetic acid / tetrahydrofuran / 0.25 h / 20 °C

2.2: 20 °C

With dimethylsulfide borane complex; acetic acid; In tetrahydrofuran;

upstream raw materials:

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester

benzaldehyde

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate